Revolutionizing viral disease treatment: Phase separation and lysosome/exosome targeting as new areas and new paradigms for antiviral drug research

Drug Discov Today. 2024 Jan 18;29(3):103888. doi: 10.1016/j.drudis.2024.103888. Online ahead of print.ABSTRACTWith the advancement of globalization, our world is becoming increasingly interconnected. However, this interconnection means that once an infectious disease emerges, it can rapidly spread worldwide. Specifically, viral diseases pose a growing threat to human health. The COVID-19 pandemic has underscored the pressing need for expedited drug development to combat emerging viral diseases. Traditional drug discovery methods primarily rely on random screening and structure-based optimization, and new approaches are required to address more complex scenarios in drug discovery. Emerging antiviral strategies include phase separation and lysosome/exosome targeting. The widespread implementation of these innovative drug design strategies will contribute towards tackling existing viral infections and future outbreaks.PMID:38244674 | DOI:10.1016/j.drudis.2024.103888
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Source Type: research