Solubilization of drugs using beta-cyclodextrin: Experimental data and modeling

In this study, the solubility enhancement of some drugs in the presence of 10 mM βCD at 25°C was experimentally determined or collected from the literature. Two different models to predict the solubilization by βCD were developed by binary logistic regression using structural properties of drugs with more than 80% accuracy. Polar surface area and excess molar refraction are the main parameters for estimating solubilization by βCD. Moreover, other descriptors related to hydrophobicity and the capability of hydrogen bonding formation of molecules could improve the accuracy of the established models.PMID:38340807 | DOI:10.1016/j.pharma.2024.02.003
Source: Annales Pharmaceutiques Francaises - Category: Drugs & Pharmacology Authors: Source Type: research