Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy

ConclusionOverall, we report a previously unappreciated fatty acid receptor, GPR84, that serves as an important metabolic sensing switch for orchestrating anti-tumorigenic macrophage polarization. Pharmacological agonists of GPR84 hold promise to reshape and reverse the immunosuppressive TME, and thereby restore responsiveness of cancer to overcome resistance to immune checkpoint blockade.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research