Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat.

Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat. Int J Clin Exp Pathol. 2015;8(4):3503-12 Authors: Yu R, Mao J, Yang Y, Zhang Y, Tian Y, Zhu J Abstract OBJECTIVE: To explore the protective effects of calcitriol on diabetic nephropathy by modulating the expressions of transforming growth factor-beta 1 (TGF-β1) and Cdc42 interacting protein-4 (CIP4). METHODS: Streptozotocin-induced diabetic nephropathy rats (n=36) were randomly divided into control group (control-H, control-M, control-L) and calcitriol group (calcitriol-H, calcitriol-M, calcitriol-L). The expression of TGF-β1 gradually decreased in control-H, control-M and control-L subgroups by injection of different virus vectors. Peanut oil and calcitriol were given to control and calcitriol group, respectively. The expressions of TGF-β1 and CIP4 in kidney, the pathology, and the renal function and lipid profiles were compared between control and calcitriol treatment groups. RESULTS: In the control group, the higher level of TGF-β1 was associated with more severe glomerular pathology (P
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research

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This study assesses the current practices of physicians in Lebanon routinely involved in ischemic stroke (IS) management. We conducted a prospective observational study of patients hospitalized at 8 different Lebanese hospitals in the period August 1, 2015 to July 31, 2016, with a diagnosis of acute stroke. Baseline characteristics and data on diagnostic studies, as well as treatments received during hospitalization and at discharge, were collected and analyzed. Two hundred and three strokes/transient ischemic attacks (TIAs) were recorded but only 173 patients (85%) with ischemic events were included in the study. The pati...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research
Conditions:   Cardiovascular Risk Factor;   Pre Diabetes;   High Blood Pressure;   Elevated LDL Cholesterol Interventions:   Other: Exercise Time;   Behavioral: Supervised Group Exercise Sponsors:   United Arab Emirates University;   Mohammed Bin Rashid University of Medicine and Health Sciences Not yet recruiting
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In the absence of an effective drug or vaccine against novel severe acute respiratory syndrome corona virus (SARS-Cov-2) till date, “repurposing approach” of old pharmaceuticals has been applied to combat against 2019-coronavirus disease (COVID-19). Hydroxychloroquine, anti-retrovirals, type-1 angiotesin receptor blockers, statin, vitamin D, melatonin etc are being tried with questionable benefits [1]. While there are intens ive debates regarding safety of different classes of antidiabetics at the advent of COVID-19 [2,3], multiple ongoing studies are evaluating the adjuvant role of various antidiaetics like di...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Letter to the Editor Source Type: research
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Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
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Source: Clinics in Geriatric Medicine - Category: Geriatrics Authors: Source Type: research
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Source: Basic Research in Cardiology - Category: Cardiology Source Type: research
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Source: Heart and Vessels - Category: Cardiology Source Type: research
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Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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