Metal-Free N-Formylation of Amines Using Carbohydrates as C1 Synthon via C –C Bond Cleavage

Synthesis DOI: 10.1055/a-2241-6697 Formamide group is an important part of many drug molecules, and herein a process for N-formylation of amines using carbohydrates as the C1 synthon under oxidative metal-free reaction conditions has been reported for the first time. Literature syntheses of formamides uses toxic, moisture sensitive and costly reagents under harsh reaction conditions. Our metal-free formylation is a facile, economical, and an efficient process of broad substrate scope that has led to the synthesis of thirty-three N-formylated compounds in excellent isolated yields. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Synthesis - Category: Chemistry Authors: Tags: paper Source Type: research