Optimal Rabbit Antithymocyte Pharmacokinetics (PK) Is Associated with Improved Disease-Free Survival (DFS) in TCR- Αβ/CD19-Depleted Pediatric Haploidentical Hematopoietic Cell Transplantation for Hematologic Malignancies

Rabbit antithymocyte globulin (rATG; Thymoglobulin ®) is often included as part of conditioning prior to TCR-αβ/CD19-T-cell depleted (AB-TCD) haploidentical hematopoietic cell transplantation (haplo-HCT) for pediatric patients with hematologic malignancies. PK models demonstrate that weight-based dosing of rATG generally results in higher exposur e pre- and post-HCT for older patients. We hypothesized that the inferior DFS noted in patients ≥10 years of age undergoing AB-TCD haploidentical HCT in our earlier manuscript (Pulsipher, Blood 2022) was due to excessive rATG exposure.

Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Christopher C. Dvorak, Lucia Holbrook-Brown, Janel Renee Long-Boyle, Hisham Abdel-Azim, Alice Bertaina, Anant Vatsayan, Julie A Talano, Nancy J. Bunin, Eric J Anderson, Allyson Flower, Nahal Lalefar, Christine S. Higham, Neena Kapoor, Maryanne A Odinakach Tags: 105 Source Type: research