Nuclear miR-204-3p mitigates metabolic dysfunction-associated steatotic liver disease in mice

Accumulating evidence has indicated the presence of mature miRNAs in the nucleus, but their effects on steatohepatitis remain elusive. We have previously demonstrated that the intranuclear miR-204-3p in macrophages protects against atherosclerosis, which shares multiple risk factors with metabolic dysfunction-associated steatotic liver disease (MASLD). Herein, we aimed to explore the functional significance of miR-204-3p in steatohepatitis.

Source: Journal of Hepatology - February 5, 2024 Category: Gastroenterology Authors: Zhaowei Zou, Xiu Liu, Jie Yu, Tao Ban, Ziyi Zhang, Peiqi Wang, Renli Huang, Fuxin Zheng, Yafei Chang, Wanli Peng, Yubo Tang, Xiaoqing Feng, Ziying Zhao, Xiaofei Lv, Shuai Huang, Jiawei Guo, Yonghua Tuo, Zhijun Zhou, Sijia Liang Tags: Research Article Source Type: research