Klippel-trenaunay syndrome and pregnancy – the case report

Introduction: Klippel-Trenaunay Syndrome (KTS) is an extremely rare condition (occurrence 1:100,000) that is associated with the abnormal development of blood vessels, soft tissues (skin and muscles), and bones. A triad of symptoms characterizes the disease: a red birthmark called a port-wine stain, abnormal overgrowth of soft tissues and bones, and vein malformations. The recognized cause of KTS is genetic mutations, primarily in the PIK3CA gene. During pregnancy, there is a significant increase in the risk of venous thromboembolism, thrombotic episodes, and severe, life-threatening postpartum haemorrhage.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Source Type: research