A comparative analysis of non-invasive preimplantation genetic testing for aneuploidies using next-generation sequencing on spent culture media versus trophectoderm

Ni-PGTA (Non-invasive Preimplantation Genetic Testing for Aneuploidy) is a relatively new testing method that analyzes spent culture medium from in vitro fertilization (IVF) embryos to determine the genetic makeup of the embryos. This non-invasive approach eliminates the need for biopsy and allows for the identification of chromosomal abnormalities such as aneuploidy. The utility of ni-PGTA is to provide an efficient, accurate, and safe method for preimplantation genetic screening. The concordance between ni-PGTA and traditional biopsy-based methods for detecting aneuploidy is high, but still further research is needed to fully evaluate its accuracy and reliability.

Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Anna Bednarska-Czerwi ńska, Anna Strychalska, Wojciech Sierka, Dariusz Mercik, Emilia Morawiec, Adam Pudełko, Joanna Smoleń-Dzirba, Anna Kokot, Natalia Jodłowiec-Lubańska, Klaudia Simka-Lampa, Urszula Wróblewska, Patrycja Mermer Source Type: research