A Novel Approach for Pancreas Transcriptomics Reveals the Cellular Landscape in Homeostasis and Acute Pancreatitis

Acinar cells produce digestive enzymes that impede transcriptomic characterization of the exocrine pancreas. Thus, single-cell RNA-sequencing (scRNA-seq) studies of the pancreas underrepresent acinar cells relative to histological expectations, and a robust approach to capture pancreatic cell responses in disease states is needed. We sought to innovate a method that overcomes these challenges to accelerate study of the pancreas in health and disease.

Source: Gastroenterology - February 5, 2024 Category: Gastroenterology Authors: Katherine J. Aney, Woo-Jeong Jeong, Andres F. Vallejo, Cassandra Burdziak, Ethan Chen, Austin Wang, Pal Koak, Kellie Wise, Kirk Jensen, Dana Pe ’er, Stephanie K. Dougan, Luciano Martelotto, Sahar Nissim Tags: Basic and Translational - Pancreas Source Type: research