Effects of Proton Pump Inhibitors on Esophageal Remodeling and Fibrosis in Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) is an immune-mediated, progressive fibrostenotic disease. Although proton pump inhibitors (PPIs) are a first-line EoE treatment due to their anti-inflammatory effects, their effects on remodeling/fibrosis – which are likely driven in part by transforming growth factor β (TGF-β) are not fully understood.

Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Colby Sharlin, Yuki Maekawa, Hiroki Sato, Kazuhiro Matsuyama, Seung Kim, Kasumi Osonoi, Naoya Sakai, Garrett Osswald, Mark Rochman, Ting Wen, Evan Dellon, Marc Rothenberg, Tetsuo Shoda Source Type: research