IgE Binding and Cross-reactivity to Linear and Conformational Epitopes of Peanut and Walnut Vicilin-buried Peptides

Peanut-allergic individuals can exhibit clinically-relevant IgE cross-reactivity to various tree nuts, particularly walnut. Vicilin-buried peptides (VBPs) found in vicilin leader sequences (LS) are a new class of allergens in peanut and tree nuts that contribute to IgE cross-reactivity. The contribution of the linear and conformational epitopes to cross-reactivity of peanut and walnut VBPs is assessed here.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research