Decreased β-catenin protein in lungs from human congenital diaphragmatic hernia archival pathology specimens: A case-control study

Lung hypoplasia contributes to congenital diaphragmatic hernia (CDH) associated morbidity and mortality. Changes in lung wingless-type MMTV integration site family member (Wnt)-signalling and its downstream effector beta-catenin (CTNNB1), which acts as a transcription coactivator, exist in animal CDH models but are not well characterized in humans. We aim to identify changes to Wnt-signalling gene expression in human CDH lungs and hypothesize that pathway expression will be lower than controls.

Source: Journal of Pediatric Surgery - February 3, 2024 Category: Surgery Authors: Martin A. Prusinkiewicz, Chanhyeok Park, Claire Cheung, Ying Jie Li, Bethany Poon, Erik D. Skarsgard, Pascal M. Lavoie, Anna F. Lee, Martina Mudri Source Type: research