IgG glycosylation associates with risk of progression from latent to active tuberculosis

Glycosylation motifs shape antibody structure, stability and antigen affinity and play an important role in antibody localization and function. Serum IgG glycosylation profiles are significantly altered in infectious diseases, including tuberculosis (TB), but have not been studied in the context of progression from latent to active TB.

Source: Journal of Infection - February 1, 2024 Category: Infectious Diseases Authors: Julie G Burel, Wenjun Wang, Manfred Wuhrer, Martin Dedicoat, Thomas E Fletcher, Adam F Cunningham, Matthew K O ’Shea Source Type: research