Beh çet’s Disease as a Canker Sore: MHC-I-Opathy Versus Behcet’s Spectrum Disorders

AbstractPurpose of ReviewBeh çet’s disease is a chronic multisystemic inflammatory disorder characterized by recurrent oral ulcers and a close association withHLA-B*51. This review summarizes the clinical and genetic features of Beh çet’s disease and compares susceptibility genes with those of other HLA class I-associated and stomatitis-related diseases.Recent FindingsIn Beh çet’s disease, recently identified non-HLA susceptibility genes are involved in the innate and acquired immune functions. An epistatic interaction betweenHLA-B*51 andERAP1 is considered to play a pathogenic role in the disease. Similar findings have been also shown in other HLA class I-associated diseases, leading to a new concept of MHC-I-opathy.Immune-related non-HLA susceptibility genes are shared among Beh çet’s disease, recurrent aphthous stomatitis, and periodic fever aphthous stomatitis and adenitis syndrome, leading to another novel concept of Behçet’s spectrum disorders.SummaryRecent genetic studies have shown that Beh çet’s disease has both features of MHC-I-opathy and Behçet’s spectrum disorders.

Source: Current Oral Health Reports - January 31, 2024 Category: Dentistry Source Type: research