Challenges to genetic testing for germline mutations associated with breast cancer among African Americans Authors

Cancer is a genomic disease in that gene alterations drive the cellular proliferation and immune surveillance abnormalities that facilitate malignant initiation and progression. Hereditary genetic factors play a vital role that underlies cancer risk and prognosis. The National Comprehensive Cancer Network (NCCN) guidelines recommend genetic testing for individuals with a personal history of breast cancer with specific features ( ≤50 years old, or any age to aid in systemic treatment decisions in the adjuvant or metastatic setting, specific histologies, male breast cancer, and Ashkenazi Jewish ancestry).
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Hot Topic Source Type: research