The Sub-Post-Tetanic “Bergin Zone” of Paralysis and its Impact on Neuromuscular Monitoring and Reversal

In 1846, the experiments of Claude Bernard showed that curare injected into the limb of a frog prevented muscle contractions from nerve stimulation, however, the muscle continued to respond when stimulated directly. The discovery of neuromuscular blocking agents revolutionized the practice of anesthesia with the synthesis of gallamine in 1947. The ability to reliably produce muscle weakness allowed for a reduction in amnestics and analgesics as well as their associated side effects and this was the genesis of today ’s balanced anesthetic technique.
Source: Journal of PeriAnesthesia Nursing - Category: Nursing Authors: Tags: Research News Source Type: research