A conceptual framework for cautious escalation of anticancer treatment: how to optimize overall benefit and obviate the need for de-escalation trials

In clinical cancer research investigating new therapies, it is of utmost importance to characterize the balance between treatment burden and benefit and to determine the optimal efficacy threshold above which additive toxicity would not be counterbalanced by net additive benefit.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Controversy Source Type: research