Opportunities for Improving Biopsy and Non-Biopsy-Based Diagnosis of Celiac Disease

The accumulating data regarding a non-biopsy diagnosis of celiac disease has led to its adoption in certain scenarios, though debate on whether and when to use non-biopsy criteria in clinical practice remains ongoing. Despite the growing popularity and evidence basis for a biopsy-free approach to diagnosis in the context of highly elevated serologies, there will nevertheless continue to be a role for a biopsy in some groups. The present review summarizes the current evidence supporting a non-biopsy approach, arguments supporting continued reliance on biopsy, and focuses on opportunities to improve both approaches.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research