Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory response and delay atherosclerosis progression

This study aims to investigate the impact of sulfotransferase family 2b member 1 (SULT2B1) on the inflammatory response of macrophages and the progression of AS. Here, we reported that SULT2B1 expression increased with the progression of AS. In AS model mice, knockdown of Sult2b1 led to remission of AS and reduced inflammation levels. Further exploration of the downstream molecular mechanisms of SULT2B1 revealed that suppressing Sult2b1 in macrophages resulted in decreased levels of 25HC3S in the nucleus, elevated expression of Lxr, and increased the transcription of Lncgga3-204.

Source: Translational Research - January 27, 2024 Category: Research Authors: Hangyu Pan, Tongwei Wu, Kang Huang, Zhongzhou Guo, Hongbin Liang, Ping Lyu, Hui Huang, Xinyi Feng, Qianqian Wang, Jing Hu, Yihua He, Zhigang Guo, Mengzhuo Yin, Yanan Zhang Source Type: research