A comparative in vitro study of the anticoagulant effect of branded versus generic rivaroxaban

Several generic formulations of rivaroxaban were recently marketed to be used interchangeably with their branded equivalent. However, there have been no previously published studies that directly compared the in vitro anticoagulant effect of branded vs. generic rivaroxaban. The aim of this in vitro study was to compare the effects of three raw rivaroxaban materials, obtained from the branded (Xarelto ®) and two generic (Rivarolto® and Rivaroxaban Sandoz®) rivaroxaban formulations on an array of coagulation assays.

Source: Thrombosis Research - January 23, 2024 Category: Hematology Authors: Karl Mangion, Kevin Vella, Alex Gatt, Amy Marie Vella, Marica Borg, Denise Borg-Aquilina, Jonathan Douxfils, Liberato Camilleri, Nicoletta Riva Tags: Full Length Article Source Type: research