PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

Expression quantitative trait loci (eQTL) offer insights into the regulatory mechanisms of trait-associated variants, but their effects often rely on contexts that are unknown or unmeasured. We introduce PICAL...

Source: Genome Biology - January 22, 2024 Category: Genetics & Stem Cells Authors: Martijn Vochteloo, Patrick Deelen, Britt Vink, Ellen A. Tsai, Heiko Runz, Sergio Andreu-S ánchez, Jingyuan Fu, Alexandra Zhernakova, Harm-Jan Westra and Lude Franke Tags: Method Source Type: research