Ketamine in the treatment of refractory and super-refractory status epilepticus: experience from two centres.

Status epilepticus (SE) is a clinical situation resulting from the failure of mechanisms that terminate seizures and/or the onset of mechanisms that abnormally prolong seizures [1]. It is referred to as refractory SE (RSE) if it continues despite parenteral administration of an adequate dose of a benzodiazepine and an antiseizure drug (ASD), and super-RSE (SRSE) if it continues 24 hours after the start of treatment with anaesthetics [2]. SE progresses to RSE in 23%-48% of patients, and to SRSE in 22% [3]; both situations are associated with high morbidity and mortality [4].

Source: Seizure: European Journal of Epilepsy - January 21, 2024 Category: Neurology Authors: Manuel Garc ía-Ruiz, Pablo Mayo Rodríguez, Luca Palliotti, Clara Lastras, María Romeral-Jiménez, Irene García Morales, Cándido Pardo Rey, Marc Rodrigo-Gisbert, Daniel Campos-Fernández, Estevo Santamarina, Beatriz Parejo Carbonell Source Type: research