Analysis of NETs (neutrophil extracellular traps) in coronary thrombus and peripheral blood of patients with ST-segment elevation myocardial infarction

Neutrophil extracellular traps (NETs) are modified chromatin structures extruded by neutrophils in response to specific stimuli, bound to cytoplasmic and granular proteins. Apart from a protective role against pathogens, NETs may exhibit potent proinflammatory and prothrombotic properties when dysregulated. NETs have been found in coronary thrombi and seem to be deleterious in this clinical setting; NET burden has been associated with infarct size directly [1] and with unfavorable short-term prognosis in patients with ST-segment elevation myocardial infarction (STEMI) [2,3].

Source: Thrombosis Research - January 20, 2024 Category: Hematology Authors: Ana Blasco, Axel Rosell, Raquel Castej ón, María-José Coronado, Ana Royuela, Elvira Ramil, Silvia Elorza, Charlotte Thålin, Paloma Martín, Basilio Angulo, Beatriz Rascón, Sergio García-Gómez, Inuntze Zabala, Javier Ortega, Lorenzo Silva, Carmen Be Tags: Letter to the Editors-in-Chief Source Type: research