806 Validation of the fetal lamb model of complex gastroschisis

Despite perceived favorable outcomes, complex Gastroschisis (cGS) has a significant morbidity such as sepsis, necrotizing enterocolitis, short bowel syndrome and bowel obstruction. A realistic animal model is lacking to enable further investigation of the pathogenesis of bowel dysfunction and development of novel prenatal therapies. We aimed to develop and validate a fetal lamb model of cGS.

Source: American Journal of Obstetrics and Gynecology - January 1, 2024 Category: OBGYN Authors: Luc Joyeux, David Basurto, Kanokwaroon Watananirun, Tom Bleeser, Ignacio J. Valenzuela, Tomohiro Arai, Inge Depoortere, Alison Accarie, Tim Vanuystel, Michael Aertsen, Alex Menys, Paolo De Coppi, Larry H. Hollier, Michael A. Belfort, Jan Deprest, Sundeep Source Type: research