Interleukin-33/ST2 Axis Involvement in Atrial Remodeling and Arrhythmogenesis

This study explored the pathological effects of the IL-33/ST2 axis on atrial remodeling and arrhythmogenesis. Patch clamping, confocal microscopy, and Western blotting were used to analyze the electrical characteristics of and protein activity in atrial myocytes (HL-1) treated with recombinant IL-33 protein and/or ST2-neutralizing antibodies for 48 hrs.

Source: Translational Research - January 18, 2024 Category: Research Authors: Tzu- Yu Cheng, Yao-Chang Chen, Shao-Jung Li, Fong-Jhih Lin, Yen-Yu Lu, Ting-I Lee, Ting-Wei Lee, Satoshi Higa, Yu-Hsun Kao, Yi-Jen Chen Source Type: research