Engineered ketoreductase-catalyzed stereoselective reduction of ethyl 2 ′-ketopantothenate and its analogues: chemoenzymatic synthesis of D-pantothenic acid

Green Chem., 2024, Advance Article DOI: 10.1039/D3GC04344D, PaperPan Hu, Xiaofan Wu, Yajiao Zhang, Minjie Liu, Yuan Tao, Zedu Huang, Fener Chen An asymmetric sustainable route toD-pantothenic acid was developed, centering on the reduction of ethyl 2 ′-ketopantothenate to ethyl (R)-pantothenate, enabled by anE. coli strain co-expressing an engineered ketoreductase and glucose dehydrogenase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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