Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs

Toxicol Pathol. 2024 Jan 9:1926233231224462. doi: 10.1177/01926233231224462. Online ahead of print.ABSTRACTThis brief communication describes a rare spontaneous background lesion in the lower urinary tract of two male laboratory beagles. Proliferative lesions comprising a constellation of histological features consistent with polypoid cystitis were observed in the bladder of two adolescent dogs from a routine preclinical toxicology study. Both animals were clinically asymptomatic and had only minor alterations in urinalysis parameters. While chronic polypoid cystitis is well-recognized in adult pet dogs, this is the first reported case in purpose-bred laboratory beagles. An awareness of this uncommon background finding is important for toxicological pathologists to distinguish it from potential test article-related findings.PMID:38193523 | DOI:10.1177/01926233231224462
Source: Toxicologic Pathology - Category: Pathology Authors: Source Type: research