Macrophages in the process of osseointegration around the implant and their regulatory strategies

CONCLUSIONS: Macrophages not only promote osseointegration through immunomodulation, but also secrete a variety of cytokines, which play a key role in the angiogenic and osteogenic phases of osseointegration. There is no "good" or "bad" difference between the M1 and M2 phenotypes of macrophages, but their timely presence and sequential switching play a crucial role in implant osseointegration. In the implant surface modification strategy, the induction of sequential activation of the M1 and M2 phenotypes of macrophages is a brighter prospect for implant surface modification than inducing the polarization of macrophages to the M1 or M2 phenotypes individually, which is a promising pathway to enhance the effect of osseointegration and increase the success rate of implant surgery.PMID:38166507 | DOI:10.1080/03008207.2023.2300455

Source: Connective Tissue Research - January 3, 2024 Category: Research Authors: Xin Fang Duo Sun Yongli Li Xiao Han Yulu Gan Junjie Jiao Mengyuan Jiang Heyi Gong Yuanzheng Qi Jinghui Zhao Source Type: research