Advances in Research on Protein Arginine Methyltransferase 2: Functions and Diseases

Protein Pept Lett. 2023 Dec 28. doi: 10.2174/0109298665281395231211060535. Online ahead of print.ABSTRACTProtein arginine methylation stands as a prevalent post-translational modification process, exerting vital roles in cellular signal transduction, gene expression, and cell cycle regulation. Amidst the protein arginine methyltransferase (PRMT) family, PRMT2 stands as a less explored constituent. Nonetheless, its regulatory roles in transcriptional regulation, post-transcriptional modification, methylation activity regulation, immunoregulation, and developmental regulation have garnered attention. These capabilities enable PRMT2 to exert pivotal regulatory functions in certain malignancies, metabolic disorders, inflammatory diseases, and atherosclerosis. In this review, we highlight the structure and functions of PRMT2, emphasizing its association with diseases. We also discuss PRMT2 inhibitors and explore the potential for therapeutic targeting.PMID:38155464 | DOI:10.2174/0109298665281395231211060535
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Source Type: research