Noncanonical functions of microRNAs in the nucleus

Acta Biochim Biophys Sin (Shanghai). 2024 Jan 3. doi: 10.3724/abbs.2023268. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that play their roles in the regulation of physiological and pathological processes. Originally, it was assumed that miRNAs only modulate gene expression posttranscriptionally in the cytoplasm by inducing target mRNA degradation. However, with further research, evidence shows that mature miRNAs also exist in the cell nucleus, where they can impact gene transcription and ncRNA maturation in several ways. This review provides an overview of novel models of nuclear miRNA functions. Some of the models remain to be verified by experimental evidence, and more details of the miRNA regulation network remain to be discovered in the future.PMID:38167929 | DOI:10.3724/abbs.2023268

Source: Acta Biochimica et Biophysica Sinica - January 3, 2024 Category: Biochemistry Authors: Jiayi Gu Yuanan Li Youtong Tian Yehao Zhang Yongjun Cheng Yuanjia Tang Source Type: research