H < sub > 2 < /sub > S serves as the immunoregulatory essence of apoptotic cell death

Cell Metab. 2024 Jan 2;36(1):3-5. doi: 10.1016/j.cmet.2023.12.006.ABSTRACTApoptosis supports tissue homeostasis and prevents immune disorders by removing damaged and functionally aberrant cells. Here, Ou et al. utilized genetic, pharmacological, and proteomic approaches focused on sulfur amino acid catabolism to discover that hydrogen sulfide (H2S) release during apoptosis suppresses Th17 cell differentiation, thus providing therapeutic targets for autoimmune diseases.PMID:38171337 | DOI:10.1016/j.cmet.2023.12.006

Source: Cell Metabolism - January 3, 2024 Category: Cytology Authors: Christopher Hine Andr ás K Ponti Mar ía Ángeles Cáliz-Molina Alejandro Mart ín-Montalvo Source Type: research