Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics

Antimicrob Agents Chemother. 2024 Jan 3:e0139323. doi: 10.1128/aac.01393-23. Online ahead of print.ABSTRACTAminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF) penetration are lacking. We estimated the extent and rate of penetration for five aminoglycosides via population pharmacokinetics from eight published studies. The area under the curve in ELF vs plasma ranged from 50% to 100% and equilibration half-lives from 0.61 to 5.80 h, indicating extensive system hysteresis. Aminoglycoside ELF peak concentrations were blunted, but overall exposures were moderately high.PMID:38169309 | DOI:10.1128/aac.01393-23

Source: Antimicrobial Agents and Chemotherapy - January 3, 2024 Category: Microbiology Authors: Eunjeong Shin Yongzhen Zhang Jieqiang Zhou Yinzhi Lang Alaa R M Sayed Carolin Werkman Yuanyuan Jiao Monika Kumaraswamy Zackery P Bulman Brian M Luna J ürgen B Bulitta Source Type: research