Methotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis

Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis. FLS overexpress bone morphogenetic protein 4 (BMP...

Source: Pediatric Rheumatology - January 2, 2024 Category: Rheumatology Authors: Megan M. Simonds, Samuel T. Freer and Anne Marie C. Brescia Tags: Research article Source Type: research