Inflammation and the pathogenesis of atherosclerosis

Vascul Pharmacol. 2023 Dec 28;154:107255. doi: 10.1016/j.vph.2023.107255. Online ahead of print.ABSTRACTThe notion that inflammation contributes to atherosclerosis has now gained considerable currency. Inflammation participates in atherosclerosis inception, progression, and thrombotic complications. Induced expression of endothelial leukocyte adhesion molecules and chemoattractant cytokines recruit blood cells to the arterial intima. Lesions can contain virtually every type of leukocyte. Monocytes mature into macrophages and imbibe lipids becoming foam cells, a hallmark of the atherosclerotic lesion. T lymphocytes can instruct the more numerous macrophages to express genes involved in the progression of the atheroma and its eventual destabilization. Inflammation is becoming clinically actionable to refine risk prediction, allocate treatments, and as a therapeutic target.PMID:38157682 | DOI:10.1016/j.vph.2023.107255
Source: Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research