Prediction of drug –drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approach

This study aimed to develop a physiologically-based pharmacokinetic (PBPK) model to predict changes in the pharmacokinetics (PK) and pharmacodynamics (PD, PDE4 inhibition) of roflumilast (ROF) and ROF N-oxide ...

Source: BMC Clinical Pharmacology - January 2, 2024 Category: Drugs & Pharmacology Authors: Guangwei Jia, Congcong Ren, Hongyan Wang and Caixia Fan Tags: Research Source Type: research