Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21)

CONCLUSIONS: Our results suggested that OS and DFS were unaffected by ACAs. Nonetheless, in the subgroup of patients older than 60, the existence of ACAs or trisomy 8 appeared to impact OS and DFS negatively. Individuals with t(15;17) alone had a higher DFS and were more susceptible to ATRA + ATO/RIF + CH than individuals with t(15;17) ACAs.PMID:38149662 | DOI:10.1080/16078454.2023.2293513

Source: Hematology - December 27, 2023 Category: Hematology Authors: Lin Liu Jinghan Wang Huan Xu Shuqi Zhao Lu Wang Jiansong Huang Huanping Wang Hongyan Tong Jie Jin Source Type: research