The genetic landscape of age-related hearing loss

Trends Genet. 2023 Dec 30:S0168-9525(23)00260-3. doi: 10.1016/j.tig.2023.12.001. Online ahead of print.ABSTRACTAge-related hearing loss (ARHL) is a prevalent concern in the elderly population. Recent genome-wide and phenome-wide association studies (GWASs and PheWASs) have delved into the identification of causative variants and the understanding of pleiotropy, highlighting the polygenic intricacies of this complex condition. While recent large-scale GWASs have pinpointed significant SNPs and risk variants associated with ARHL, the detailed mechanisms, encompassing both genetic and epigenetic modifications, remain to be fully elucidated. This review presents the latest advances in association studies, integrating findings from both human studies and model organisms. By juxtaposing historical perspectives with contemporary genomics, we aim to catalyze innovative research and foster the development of novel therapeutic strategies for ARHL.PMID:38161109 | DOI:10.1016/j.tig.2023.12.001
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Source Type: research