Advances in understanding of cardiac sodium channel structure/function and their relation to disease pathogenesis and treatment

The cardiac voltage-gated sodium channel Nav1.5 plays a critical role in maintaining normal cardiac excitability. Nav1.5, the primary cardiac Nav α-subunit, has been extensively implicated in the etiology of arrhythmias. Indeed, dysfunctions in Nav1.5 due to congenital or acquired defects have been associated with a wide range of pathologic manifestations, including sinus nodal dysfunction, atrial and ventricular arrhythmias, and heart failu re.
Source: Heart Rhythm - Category: Cardiology Authors: Tags: Top Stories Source Type: research