The epigenome under pressure: On regulatory adaptation to chronic stress in the brain

Curr Opin Neurobiol. 2023 Dec 22;84:102832. doi: 10.1016/j.conb.2023.102832. Online ahead of print.ABSTRACTChronic stress (CS) can have long-lasting consequences on behavior and cognition, that are associated with stable changes in gene expression in the brain. Recent work has examined the role of the epigenome in the effects of CS on the brain. This review summarizes experimental evidence in rodents showing that CS can alter the epigenome and the expression of epigenetic modifiers in brain cells, and critically assesses their functional effect on genome function. It discusses the influence of the developmental time of stress exposure on the type of epigenetic changes, and proposes new lines of research that can help clarify these changes and their causal involvement in the impact of CS.PMID:38141414 | DOI:10.1016/j.conb.2023.102832

Source: Current Opinion in Neurobiology - December 23, 2023 Category: Neurology Authors: Rodrigo G Arzate-Mejia Nancy V N Carullo Isabelle M Mansuy Source Type: research