Recent Progress in Ferroptosis Induced Tumor Cell Death by Anti-tumor Metallic complexes
Chem Asian J. 2023 Dec 27:e202301020. doi: 10.1002/asia.202301020. Online ahead of print.ABSTRACTMetal complexes represented by platinum complexes play a very important role in cancer treatment due to their diverse chemical structures and anti-tumor activities. Recently, ferroptosis has emerged as a newly occurring cell death form in the anti-tumor process. It has been reported that metal complexes could inhibit the proliferation and metastasis of tumors and combat chemotherapy resistance by targeting ferroptosis. In this review, we briefly describe ferroptosis as a fundamental process for tumor suppression and triggering anti-tumor immune responses. We summarize recent developments on metal complexes that induce ferroptosis. Finally, we outline the prospects for the application of metal complexes to the treatment of tumors based on ferroptosis and the associated problems that need to be solved, and discussed other potential research directions of metal complexes.PMID:38149729 | DOI:10.1002/asia.202301020
Source: Chemistry, an Asian Journal - Category: Chemistry Authors: Yong-Chang Zhou Tian-Kun Zhao Si-Man Tao Peng Wang Yi-Chen Guan Ke-Pei Yang Shengqiang Chen Xiuying Pu Source Type: research