Dental caries prevalence and severity positively associate with AMY1 gene copy number

ConclusionTC and CS were positively related to the AMY1GCN.Clinical relevanceDental caries has a high prevalence and a multifactorial etiology and has been related to a genetic component. Indeed, the salivary enzyme alpha-amylase could play a significant role in caries susceptibility, considering that its codifying gene (AMY1) can show variation in its gene copy number. This can be considered an important factor for the development of caries at a genetic level.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research