Age, BMI, and type2 diabetes modify the relationship between PNPLA3 and advanced fibrosis in children and adults with NAFLD

PNPLA3 G-allele is an important determinant of disease severity in NAFLD. Here, we investigated the effect of age, BMI, and type 2 diabetes mellitus (T2DM) on the relationship between PNPLA3 G-allele and advanced fibrosis in adults and children with histologically characterized NAFLD.

https://www.cghjournal.org/article/S1542-3565(23)01041-8/fulltext?rss=yes

Source: Clinical Gastroenterology and Hepatology - December 23, 2023 Category: Gastroenterology Authors: Chaowapong Jarasvaraparn, Eduardo Vilar-Gomez, Katherine P. Yates, Laura A. Wilson, Brent Neuschwander-Tetri, Rohit Loomba, Oscar Cummings, Miriam Vos, Stavra Xanthakos, Jeffrey Schwimmer, Jean P. Molleston, Arun Sanyal, James Tonascia, Naga Chalasani Source Type: research