Multiparametric Flow Cytometry in the Evaluation of Plasma Cell Proliferative Disorders: Current Paradigms for Clinical Practice

The multi-parametric flow cytometry (MFC) is technically the most valuable tool in characterization and quantification of clonal plasma cells (PCs). The MFC has a well-defined role in monitoring measurable residual disease (MRD) in MM, in estimating risks of progression in MGUS and SMM and predicting treatment outcomes. The ability of MFC to measure low levels of circulating clonal PCs has enabled non-invasive monitoring of treatment responses and risk assessment in PCPDs. The study of changes in the tumor microenvironment makes it an attractive platform to understand impact of newtherapies, especially, the immunotherapy.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Review Article Source Type: research