Assessment of quinidine-induced TdP risks using a whole-body physiologically based pharmacokinetic model linked to cardiac ionic current inhibition

In conclusion, the developed PBPK-PD model may be applied to predict the quinidine pharmacokinetics and quinidine-induced TdP risks in healthy subjects, but also simulate quinidine-induced TdP risks under disease conditions such as hypokalemia and alkalosis.PMID:38117225 | DOI:10.1002/cpt.3156
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Source Type: research