Recurrent Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 1 Syndrome

Physiol Res. 2023 Dec 17;72(S4):S423-S427.ABSTRACTPrimary hyperparathyroidism is a common endocrinopathy. Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal dominantly inherited endocrine tumor predisposition syndrome, with one of main manifestations being primary hyperparathyroidism. We retrospectively evaluated a set of 1011 patients who underwent surgery for primary hyperparathyroidism between the years 2018-2022, and found 78 (8 %) patients who underwent reoperations and 27 patients with MEN1 syndrome. In the group of patients with MEN1 syndrome, 7 (35 %) needed reoperations. Patients with multiple endocrine neoplasia syndrome have a higher risk of needing reoperation. Genetic testing can help identify MEN1 syndrome preoperatively and to better evaluate the approach to surgery.PMID:38116778

Source: Physiological Research - December 20, 2023 Category: Physiology Authors: P Lib ánský J Čarková I Kushnir M Mat ějková Běhanová K Procyklov á J Šedý M Vaculov á J V čelák V Zik án S Ad ámek Source Type: research