Atypicality index as an add-on to combined first-trimester screening for chromosomal aberrations

CONCLUSIONS: As an add-on to cFTS, the atypicality index identifies women with typical measurement profiles which may act as reassurance, whereas atypical profiles may warrant specialist referral and further investigations. In pregnancies at low risk from cFTS but with a highly atypical distribution of NT, PAPP-A, and β-hCG, the risk of a chromosomal aberration is substantially increased. The atypicality index optimizes the interpretation of pre-existing prenatal screening profiles and is not limited to cFTS markers or EFW. This article is protected by copyright. All rights reserved.PMID:38112514 | DOI:10.1002/uog.27562
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research