Directing adipose derived stem cells into epidermal-like cells through epigenetic modifiers-based protocol

Objective: Adipose derived stem cells (ADSCs) have obtained the attention in skin regeneration and wound healing for their ease of isolation, and their abundance in adipose tissue. Stem cells differentiation into specific lineage requires to enhance or repress gene activation to alter cellular phenotype, metabolic state and function. Unfortunately, the differentiation process is not always efficient especially when targeted cells do not belong to the same lineage of the stem cell origin. Epigenetic modifications play a crucial role in guiding cell development and differentiation including DNA methylation and histone deacetylation.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research