Histone deacetylase inhibitor alters adipose derived stem cells fate transition toward epidermal lineage

Objective: Histone acetylation is one of the epigenetic modifications which plays a crucial role in cell proliferation and differentiation. Induction of histone hyperacetylation modulates gene transcription which is responsible for directing the fate of stem cells. We applied a pharmacological approach for manipulating histone acetylation through the inhibition of histone deacetylases using Suberoylanilide hydroxamic acid (SAHA). Understanding the regulation of molecular mechanism will lead to potential therapeutic targets for various skin injuries.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research