Nitrogenous compounds from Aesculus wilsonii seeds

Fitoterapia. 2023 Dec 16:105783. doi: 10.1016/j.fitote.2023.105783. Online ahead of print.ABSTRACTEight nitrogenous compounds including five undescribed ones, aeswilnitrousol A (1), aeswilnitrousosides BD (2-4), and 6-(2-hydroxy-3-methylbutylamino)-8-oxoadenine (5) were isolated from the seeds of Aesculus wilsonii. Their structures and absolute configurations were established based on spectroscopic determination, calculated electronic circular dichroism (ECD) analysis, as well as chemical reaction methods. Among the three known compounds, 7 and 8 were obtained from the Aesculus genus for the first time, and 6 was gained from this plant initially. The 13C NMR data of 7 and 8 were reported for the first time. Moreover, the inhibitory effect of all the isolates against LPS-induced nitric oxide production in RAW264.7 macrophages was evaluated. As a result, compounds 2 and 8 exhibited anti-inflammatory activity in a concentration-dependent manner at 10, 25, and 50 μM.PMID:38110127 | DOI:10.1016/j.fitote.2023.105783

Source: Fitoterapia - December 18, 2023 Category: Biochemistry Authors: Huina Cao Jingya Ruan Xiaoyan Cao Yaqi Zhang Jia Hao Yuzheng Wu Yi Zhang Tao Wang Source Type: research